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Medical references for the Preventive Health Guide

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1 Safety of supplements. Vitamin C Newmark HL, ScheinerJ, et al. Amercan Journal of Clinical Nutrition. 1976; 29:645-649

2 Safety of supplements. Vitamin C HagenKamp HP. Amercan Journal of Clinical Nutrition. 1980;33:1

3 Safety of supplements. Vitamin C Hanck A, Rizekl G. Re-evaluation vitamin C. Stuttgart:Verlag Hans Huyber, 1977.

4 ‘Health benefits of selected vitamins’. Milly Ryan-Harshman, PHD, RD and Walid Aldoori, MBBCH, MPA, SCD. Can Fam Physician. 2005 July 10; 51(7): 965–968

5 ‘Water-soluble vitamins: research update’. Bruno,-E-J Jr; Ziegenfuss,-T-N. Curr-Sports-Med-Rep. 2005 Aug; 4(4): 207-13

6 ‘Dietary recommendations for vitamin D: a critical need for functional end points to establish an estimated average requirement.’ Whiting,-S.J.; Calvo,-M.S. Journal of nutrition. 2005 Feb., v. 135, no. 2 p. 304-309.

7 World Health Organisation website at http://www.who.int/nutrition/

8 US Department of Agriculture website at http://fnic.nal.usda.gov

9 US Food & Drug Administration website at http://www.fda.gov/

10 ‘Dietary Reference Intakes: Recommended Intakes for Individuals’ National Academy of Sciences. Institute of Medicine. Food and Nutrition Board.

11 ‘Vitamin and mineral requirements in human nutrition’ Second edition World Health Organization and Food and Agriculture Organization, 2004

12 Strand MD, Ray What Your Doctor Doesn't Know About Medicine May Be Killing You Thomas Nelson, Inc., 2002

13 McNamara MD, Ladd R. Doctor McNamara's Medical Resource Manual Orthomolecular Medicine, Inc., 1999

14 Pathophysiology of oxidative stress in diabetes mellitus. Journal of Diabetes and its Complications, Volume 15, Issue 4, Pages 203-210 B. Lipinski

15 Can Med Assoc J. 1985 June 15; 132(12): 1350. ‘Antibiotic-like action of essential fatty acids’

16 Stephen R Covey. The 8th Habit. From Effectiveness to Greatness (Author of 7 Habits of Highly Effective People) Free Press 2005 p19,20

17 Bairoch A. (2000). “The Enzyme Database In 2000” Nucleic Acids Res 28: 304-305.

18 Fuchs, CS, et al. "Dietary fiber and the risk of colorectal cancer and adenoma in women." New England Journal of Medicine, 21 Jan 1999:223-4.

19 Fiber Health Claims That Meet Significant Scientific Agreement, US Food and Drug Administration, http://www.cfsan.fda.gov/~dms/lab-ssa.html

20 Donatelle, Rebecca J. (2005). Health, The Basics. 6th ed. San Francisco: Pearson Education, Inc.

21 Fiber, Harvard School of Public Health, http://www.hsph.harvard.edu/nutritionsource/fiber.html

22 Lieberman, S, Bruning, N (1990). The Real Vitamin & Mineral Book. NY: Avery Group, 3.

23 "Biochemistry" by Jeremy M. Berg, John L. Tymoczko and Lubert Stryer (2002) W. H. Freeman and Co.

24 Jack Challem (1997). "The Past, Present and Future of Vitamins"

25 Mozaffarian D, Katan MB, Ascherio A, Stampfer MJ, Willett WC (April 2006). "Trans Fatty Acids and Cardiovascular Disease". New England Journal of Medicine 354 (15): 1601-1613.

26 Colgan, Dr Michael. Optimum Sports Nutrition. Your competitive Edge. Advanced Research Press, New York 1993

27 Mansell P, Reckless JP. BMJ. 1991 Aug 17; 303(6799): 379-380.

28 Koch, H. P.; Lawson, L. D. (1996). Garlic. The Science and Therapeutic Application of Allium sativum L. and Related Species (Second Edition). Williams & Wilkens.

29 Effect of garlic on cardiovascular disorders: a review. Banerjee SK, Maulik SK. Nutr J. 2002; 1: 4. published online before print November 19, 2002

30 Breithaupt-Grogler, K., et al. (1997). Protective effect of chronic garlic intake on elastic properties of aorta in the elderly. Circulation 96: 2649-2655

31 Yeh, Y-Y., et al. (1997). Garlic reduced plasma cholesterol in hypercholesterolemic men maintaining habitual diets. In: Ohigashi, H., et al. (eds). Food Factors for Cancer Prevention. Tokyo: Springer-Verlag

32 Activities of Garlic Oil, Garlic Powder, and Their Diallyl Constituents against Helicobacter pylori. O'Gara EA, Hill DJ, Maslin DJ. Appl Environ Microbiol. 2000 May; 66(5): 2269-2273.

33 Antimalarial Activity of Allicin, a Biologically Active Compound from Garlic Cloves. Coppi A, Cabinian M, Mirelman D, Sinnis P. Antimicrob Agents Chemother. 2006 May; 50(5): 1731-1737.

34 Oxidative stress in ocular disease: Does lutein play a protective role? Sylvia Santosa and Peter J.H. Jones. CMAJ. 2005 October 11; 173(8): 861–862. doi: 10.1503/cmaj.1031425.

35 Landrum, J., et al. Serum and macular pigment response to 2.4 mg dosage of lutein. in ARVO. 2000.

36 Profiling and Radical Scavenging Activity of Anthocyanins in Various Berries. Nakajima JI, Tanaka I, Seo S, Yamazaki M, Saito K. J Biomed Biotechnol. 2004; 2004(5): 241-247.

37 Anthocyanins and Human Health: An In Vitro Investigative Approach. Lila MA. J Biomed Biotechnol. 2004; 2004(5): 306-313.

38 A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age- related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol, 2001. 119(10): p. 1417-36.

39 Duncan, J.L., et al., Macular pigment and lutein supplementation in choroideremia. Exp Eye Res, 2002. 74(3): p. 371-81

40 Bent S et al (2006). "Saw Palmetto for Benign Prostatic Hyperplasia". NEJM 354: 557–566.

41 Guide to Supplements-Saw Palmetto-Berkeley Wellness Letter

42 Moreu w RA, Norton, RA, Hicks KB. Phytosterols and phytostanols lower cholesterol. Inform 1 O(6): 572-576.1999

43 American Family Physician, March 2003, American Academy of Family Physicians.

44 Update on prostate cancer chemoprevention. Pharmacotherapy, {Pharmacotherapy}, Mar 2006, vol. 26, no. 3, p. 353-9, 48 refs, ISSN: 0277-0008. Lowe-Jennifer-Fisher, Frazee-Lawrence-A.

45 Antioxidant activities of New Zealand-grown tomatoes. Int-J-Food-Sci-Nutr 2005 Dec; 56(8):597-605, ISSN: 0963-7486. Toor-R-K, Lister-C-E, Savage-G-P.

46 Effects of soy phytoestrogens on the prostate. Prostate Cancer and Prostatic Diseases, {Prostate-Cancer-Prostatic-Dis }, 20 Feb 2007 (epub: 20 2 2007), ISSN: 1365-7852. Goetzl-M-A, Vanveldhuizen-P-J, Thrasher-J-B.

47 Flavonoid and botanical approaches to prostate health. J-Alternat-Complement-Med 2002 Dec; 8(6):813-21, ISSN: 1075-5535.

48 Saw palmetto supplement use and prostate cancer risk. Nutrition and cancer, {Nutr-Cancer}, 2006, vol. 55, no. 1, p. 21-7, ISSN: 0163-5581. Bonnar-Pizzorno-Raven-M, Littman-Alyson-J, Kestin-Mark, White-Emily.

49 Complementary and Alternative Therapies For Cancer Patients Saw Palmetto-University of California at San Diego Medical Center

50 Internet survey of treatments used by parents of children with autism. Green-V-A, Pituch-K-A, Itchon-J, Choi-A, O-reilly-M, Sigafoos-J. Res-Dev-Disabil 2006 Jan-Feb; 27(1):70-84, ISSN: 0891-4222. 2006.

51 Vitamin supplementation of HIV-infected women improves postnatal child growth. Villamor-E, Saathoff-E, Bosch-R-J, Hertzmark-E, Baylin-A, Manji-K, Msamanga-G, Hunter-D-J, Fawzi-W-W. Am-J-Clin-Nutr 2005 Apr; 81(4):880-8, ISSN: 0002-9165. 2005.

52 Pilot study of a moderate dose multivitamin/mineral supplement for children with autistic spectrum disorder. Adams-J-B, Holloway-C. J-Alternat-Complement-Med 2004 Dec; 10(6):1033-9, ISSN: 1075-5535. 2004.

53 Omega-3 fatty acids in dietetics: A review (part 3). Muller-S-D. Schweiz-Z-Ganzheits-Medizin 2004 May; 16(4):223-9, ISSN: 1015-0684. 2004.

54 Zinc deficiency, part 2: Causes, symptoms, therapy. Muller-S-D. Schweiz-Z-Ganzheits-Medizin 2004 Feb; 16(1):26-32, ISSN: 1015-0684. 2004.

55 Outcome-based comparison of Ritalin versus food-supplement treated children with AD/HD. Harding-K-L, Judah-R-D, Gant-C. Altern-Med-Rev 2003 Aug; 8(3):319-30, ISSN: 1089-5159. 2003.

56 Vitamin supplement intake is related to dietary intake and physical activity: The Child and Adolescent Trial for Cardiovascular Health (CATCH). Journal of the American Dietetic Association, {J-Am-Diet-Assoc}, Dec 2006, vol. 106, no. 12, p. 2018-23, ISSN: 0002-8223. Reaves-Lindsay, Steffen-Lyn-M, Dwyer-Johanna-T, Webber-Larry-S, Lytle-Leslie-A, Feldman-Henry-A, Hoelscher-Deanna-M, Zive-Michelle-M, Osganian-Stavroula-K.

57 Vitamin preparations as dietary supplements and as therapeutic agents. Council on Scientific Affairs. JAMA : the journal of the American Medical Association, {JAMA}, 10 Apr 1987, vol. 257, no. 14, p. 1929-36, ISSN: 0098-7484.

58i Use of natural vitamin supplements in children during convalescence and in children with athletic activities. (Impiego di integratori vitaminici naturali in bambini durante periodi di convalescenza e in bambini che praticano attività sportive.) Minerva pediatrica, {Minerva-Pediatr}, Jan-Feb 1999, vol. 51, no. 1-2, p. 1-9, 48 refs, ISSN: 0026-4946.Savino-F, Bonfante-G, Madon-E.

58ii Vitamin supplementation for preventing miscarriage. Cochrane database of systematic reviews (Online), {Cochrane-Database-Syst-Rev}, 2005 (epub), no. 2, p. CD004073, 90 refs, ISSN: 1469-493X. Rumbold-A, Middleton-P, Crowther-C-A.

59 Improved mood and behavior during treatment with a mineral-vitamin supplement: an open-label case series of children. Journal of child and adolescent psychopharmacology, {J-Child-Adolesc- Psychopharmacol}, Spring 2004, vol. 14, no. 1, p. 115-22, ISSN: 1044-5463. Kaplan-Bonnie-J, Fisher-Jennifer-E, Crawford-Susan-G, Field-Catherine-J, Kolb-Bryan.

60 Nutrition and health--vitamins and vitamin supplements. (Voeding en gezondheid--vitaminen en vitaminesupplementen). Nederlands tijdschrift voor geneeskunde, {Ned-Tijdschr-Geneeskd}, 19 Apr 2003, vol. 147, no. 16, p. 752-6, 18 refs, ISSN: 0028-2162. Schrijver-J, van-den-Berg-H.

61 Oral clefts and vitamin supplementation. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, {Cleft-Palate-Craniofac-J}, Jan 2001, vol. 38, no. 1, p. 76-83, ISSN: 1055-6656. Loffredo-L-C, Souza-J-M, Freitas-J-A, Mossey-P-A.

62 Large scale study links vitamins to intelligence. Podmore-J. Hospital-doctor 1991 Mar 7:39. 1991.

63 Effect of vitamin and mineral supplementation on intelligence of a sample of schoolchildren. Benton-D, Roberts-G. Lancet 1988 Jan 23; 1(8578):140-3.

64 Osteoporosis and supplements. Clinical calcium, {Clin-Calcium}, Jun 2005, vol. 15, no. 6, p. 1042-4, 7 refs, ISSN: 0917-5857. Kido-Makiko. Department of Nephrology and Endocrinology, University of Tokyo, Faculty of Medicine.

65 Selection of the supplement in calcium intake. Clinical calcium, {Clin-Calcium}, Jan 2004, vol. 14, no. 1, p. 60-4, ISSN: 0917-5857. Tsukahara-Noriko, Ezawa-Ikuko.

66 Symposium on the origins and consequences of obesity, Kingston, Jamaica, 28-30 November 1995. Series: Ciba Foundation symposium, 201, Publisher: John Wiley & Sons, Chichester, 1996, x,278p, ISBN: 0471965065, 9780471965060. Chadwick-Derek-J, Cardew-Gail.

67 Lower your cardiac risk to preserve future independence. A new study finds a link between cardiac risk factors in middle age and later life nursing home admissions. Health news (Waltham Mass.), {Health-News}, Sep 2006, vol. 12, no. 9, p. 3-4, ISSN: 1081-5880.

68 Relation of body mass index in young adulthood and middle age to Medicare expenditures in older age. JAMA : the journal of the American Medical Association, {JAMA}, 8 Dec 2004, vol. 292, no. 22, p. 2743-9, ISSN: 1538-3598. Daviglus-Martha-L, Liu-Kiang, Yan-Lijing-L, Pirzada-Amber, Manheim-Larry, Manning-Willard, Garside-Daniel-B, Wang-Renwei, Dyer-Alan-R, Greenland-Philip, Stamler-Jeremiah.

69 Report on the 2nd World Congress on Fetal Origins of Adult Disease, Brighton, U.K., June 7-10, 2003. Pediatric research, {Pediatr-Res}, May 2004 (epub: 05 Feb 2004), vol. 55, no. 5, p. 894-7, ISSN: 0031-3998. Hanson-Mark, Gluckman-Peter, Bier-Dennis, Challis-John, Fleming-Tom, Forrester-Terrence, Godfrey-Keith, Nestel-Penelope, Yajnik-Chittaranjan.

70 Calcium and bone health in children: a review. American journal of therapeutics, {Am-J-Ther}, Jul-Aug 1997, vol. 4, no. 7-8, p. 259-73, 94 refs, ISSN: 1075-2765. Stallings-V-A.

71 American Heart Association Call to Action: Obesity as a Major Risk Factor for Coronary Heart Disease Robert H. Eckel, MD; Ronald M. Krauss, MD for the AHA Nutrition Committee

72 U.S. Centers For Disease Prevention And Control at www.cdc.gov

73 Orthopedic Surgeon Bones Up on Nutrition by Joanne Halbrecht, MD Orthopedic Technology Review Nov-Dec 2006

74 Osteoporosis and supplements. Clinical calcium, {Clin-Calcium}, Jun 2005, vol. 15, no. 6, p. 1042-4, 7 refs, ISSN: 0917-5857. Kido-Makiko.

75 The Franklin Institute Resources For Science Learning at http://www.fi.edu/biosci/blood/platelet.html

76 Selection of the supplement in calcium intake. Clinical calcium, {Clin-Calcium}, Jan 2004, vol. 14, no. 1, p. 60-4, ISSN: 0917-5857. Tsukahara-Noriko, Ezawa-Ikuko.

77 Harvard School of Public Health at http://www.hsph.harvard.edu/nutritionsource/calcium.html

78 Calcium and bone health in children: a review. American journal of therapeutics, {Am-J-Ther}, Jul-Aug 1997, vol. 4, no. 7-8, p. 259-73, 94 refs, ISSN: 1075-2765. Stallings-V-A.

79 Preventive action of vitamin C on nitrosamine formation. International journal for vitamin and nutrition research. {Int-J-Vitam-Nutr-Res-Suppl}, 1989, vol. 30, p. 109-13, 28 refs, ISSN: 0373-0883. Tannenbaum-S-R.

80 The Linus Pauling Institute, Oregon State University at http://lpi.oregonstate.edu/ss02/suh.html

81 Vitamin C is an important cofactor for both adrenal cortex and adrenal medulla. Endocrine research, {Endocr-Res}, Nov 2004, vol. 30, no. 4, p. 871-5, 26 refs, ISSN: 0743-5800. Patak-P, Willenberg-H-S, Bornstein-S-R.

82 Harvard School of Public Health at http://www.hsph.harvard.edu/nutritionsource/vitamins.html

83 Carcinogenesis, Vol. 20, No. 9, 1737-1745, September 1999 Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation–promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent. Jifu Zhao, Jiannong Wang, Yingjie Chen and Rajesh Agarwal

84 Flavonoids (isoflavonoids and neoflavonoids). IUPAC Compendium of Chemical Terminology

85 Ector BJ, Magee JB, Hegwood CP, Coign MJ., Resveratrol Concentration in Muscadine Berries, Juice, Pomace, Purees, Seeds, and Wines.

86 University of Scranton at http://www.sdearthtimes.com/et0301/et0301s24.html

87 Resveratrol Concentration in Muscadine Berries, Juice, Pomace, Purees, Seeds, and Wines. B. J. Ector, J. B. Magee , C. P. Hegwood, and M. J. Coign Am. J. Enol. Vitic. 47:1:57-62 (1996)

88 Winter 2000/2001 issue of the Journal of Medicinal Food.

89 Polyphenolics in Grape Seeds - Biochemistry and Functionality. J-Med-Food 2003 Winter; 6(4):291-9 Shi-J, Yu-J, Pohorly-J-E, Kakuda-Y.

90 Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells. Clinical cancer research : an official journal of the American Association for Cancer Research, {Clin-Cancer-Res}, 15 Oct 2006, vol. 12, no. 20 Pt 1, p. 6194-202 Kaur-Manjinder, Singh-Rana-P, Gu-Mallikarjuna, Agarwal-Rajesh, Agarwal-Chapla.

91 Neurodegeneration from mitochondrial insufficiency: nutrients, stem cells, growth factors, and prospects for brain rebuilding using integrative management. Altern-Med-Rev 2005 Dec; 10(4):268-93, ISSN: 1089-5159. Kidd-P-M.

92 Coenzyme Q10: a review. Hosp Pharm. 2001;36(1):51-66. Al-Hasso.

93 Relative bioavailability of coenzyme Q10 formulations in human subjects. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition, {Int-J-Vitam-Nutr-Res}, 1998, vol. 68, no. 2, p. 109-13, ISSN: 0300-9831. Chopra-R-K, Goldman-R, Sinatra-S-T, Bhagavan-H-N.

94 University of Maryland Medical Centre website at: www.umm.edu/altmed/ConsSupplements/CoenzymeQ10cs.h

95 Antioxidative effect of dietary coenzyme Q10 in human blood plasma. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition, {Int-J-Vitam-Nutr-Res}, 1994, vol. 64, no. 4, p. 311-5, ISSN: 0300-9831. Weber-C, Sejersgård-Jakobsen-T, Mortensen-S-A, Paulsen-G, Hølmer-G.

96 CoQ10: "natural and essential" for the heart Better Nutrition, August, 1997 by James F. Scheer

97 Coenzyme Q-10 for migraine prophylaxis: The first RCT. Focus-Alternat-Complement-Ther 2005 Sep; 10(3):194-5, ISSN: 1465-3753. Sandor-P-S, Di-Clemente-L, Coppola-G, Saenger-U, Fumal-A, Magis-D, Siedel-L, Agosti-R-M, Schroenen-J.

98 Linus Pauling Institute, Oregon State University, at: lpi.oregonstate.edu/infocenter/othernuts/coq10

99 The role of coenzyme Q10 in heart failure. The Annals of pharmacotherapy, {Ann-Pharmacother}, Sep 2005 (epub: 26 Jul 2005), vol. 39, no. 9, p. 1522-6, 18 refs, ISSN: 1060-0280. Weant-Kyle-A, Smith-Kelly-M.

100 Coenzyme Q 10: a review. Ancient-Sci-Life 2002 Oct; 22(2):49-55, ISSN: 0257-7941. Singh-D, Jain-V, Saraf-S, Saraf-S.

For more information follow the link for ebooks; Medical eBooks

101 Role of coenzyme Q10 in clinical medicine part II. Cardiovascular disease, hypertension, diabetes mellitus and infertility. Alternat-Med-Rev 1996 Sep; 1(3):168-75. Gaby-A-R.

102 Proc Natl Acad Sci U S A. 1995 September 26; 92(20): 9388–9391. The roles of coenzyme Q10 and vitamin E on the peroxidation of human low density lipoprotein subfractions. R Alleva, M Tomasetti, M Battino, G Curatola, G P Littarru, and K Folkers Institute of Biochemistry, Faculty of Medicine, University of Ancona, Italy

103 WHO, World Health Report 2000

104 Passive smoking and the risk of coronary heart disease-A meta-Analysis of Epidemiologic studies. 1999,12,340:920-6. Jiang He et al.

105 World Heart Federation at www.worldheart.org

106 Smoking and stroke : a causative role by Aldoori MI, Rahman SH. BMJ 1998;317:962-3. 107 Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells. Cancer Lett 1996;110:41–8. Kuo SM.

108 Dietary flavonoids and cancer risk in the Zutphen Elderly Study. Nutr Cancer 1994: 22:175–84. Hertog M, Feskens EJM, Hollman PCH, et al.

109 Quercetin, an anti-oxidant bioflavonoid, attenuates diabetic nephropathy in rats. Clinical and Experimental Pharmacology and Physiology 31 (4), 244–248. Muragundla Anjaneyulu, Kanwaljit Chopra (2004)

110 Comparative bioavailability to humans of ascorbic acid alone or in a citrus extract. Am J Clin Nutr 1988;48:601–4. Vinson JA, Bose P.

111 Basic Histology: Text and Atlas (2003) Luiz Carlos Junqueira and José Carneiro

112 University of Virginia Medical School at www.med-ed.virginia.edu

113 Skin Aging Innovita Research Foundation (June 12th 2003) at http://www.innovitaresearch.org/news/03061201.html

114 Cancer Research UK at http://info.cancerresearchuk.org/cancerandresearch/

115 Caner Research Sunsmart at http://info.cancerresearchuk.org/healthyliving/sunsmart/

116 The Cancer Council Australia at http://www.cancer.org.au

117 Parabens U.S. Food & Drug Adminstration at http://www.cfsan.fda.gov/~dms/cos-para.html

118 LE Magazine April 2000 ‘Cellular Nutrition for Vitality and Longevity.’

119 Healthy for Life Newsletter January 2007 Vol. 4, No. 1 Death by Prescription, Ray D Strand, Thomas Nelson

118 Abigail Zuger, "Fever Pitch: Getting Doctors To Prescribe Is Big Business," NEW YORK TIMES January 11, 1999, pgs. A1, A13. at:http://query.nytimes.com/gst/fullpage.html?sec=health&res=9C04E6DA1731F932A25752C0A96F958260

119 Thomas J. Moore and others, "Time to Act on Drug Safety," JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION Vol. 279, No. 19 (May 20, 1998), pgs. 1571-1573.

120 Death by Medicine By Gary Null, Ph.D., PhD; Carolyn Dean MD, ND; Martin Feldman, MD; Debora Rasio, MD; and Dorothy Smith, PhD

121 The Null Hypothesis Comments on Gary Null's "Death by Medicine" by James R. Laidler, MD at: http://www.geocities.com/healthbase/null_hypothesis_laidler.html

122 Are Lipid Lowering Statins Evidence Based? J. Abramson, et al. The Lancet, January 2007

123 David W. Bates, "Drugs and Adverse Drug Reactions; How Worried Should We Be? [editorial]" JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION Vol. 279, No. 15 (April 15, 1998), pgs. 1216-1217.

124 David C. Classen and others, "Adverse Drug Events in Hospitalized Patients," JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION Vol. 277, No. 4 (January 22/29, 1997), pgs. 301-306.

125 Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA. 1998;279:1200-1204.

126 Are Lipid Lowering Statins Evidence Based? J. Abramson, et al. The Lancet, January 2007

127 Raising HDL-Cholesterol and Reducing Cardiovascular Risk. Medscape Cardiology, 2006 at: http://www.medscape.com/viewarticle/520393

128 The Homocysteine Information Site at http://www.homocysteine.net

129 American Heart Association at http://www.americanheart.org/presenter.jhtml?identifier=180

130 Symptoms of Nutritional Deficiencies, Dr. Charles L. Crist, M.D. at:http://www.drcharlescrist.com/symptomsofnd.htm

131 Cromwell WC, Otvos JD (2004). "Low-density lipoprotein particle number and risk for cardiovascular disease". Curr Atheroscler Rep 6 (5): 381-7.

132 Homocysteine Reduction How Much Is Safe? Life Extension 01/20/2006 at http://www.lef.org/protocols/heart_circulatory/homocysteine_reduction_01.htm

133 Raising HDL-Cholesterol and Reducing Cardiovascular Risk. Medscape Cardiology http://www.medscape.com/viewarticle/520393

134 Steinberg D. Antioxidant vitamins and coronary heart disease. N Engl J Med 1993;328:1487-1489

135 Reducing risk by raising HDL-cholesterol: the evidence. # European Heart Journal Supplements Vol 8 Suppl F p. F23-F29 at: http://eurheartjsupp.oxfordjournals.org/cgi/content/abstract/8/suppl_F/F23

136 Enstrom JE, Kanim LE, Klein MA. Vitamin C intake and mortality among a sample of the United States population. Epidemiology 1992;3:194-202.

137 KISHORCHANDRA GOHIL, LESTER PACKER (2002) Bioflavonoid-Rich Botanical Extracts Show Antioxidant and Gene Regulatory Activity Annals of the New York Academy of Sciences 957 (1), 70–77.

138 The Role of Macrophages in Atherosclerosis at www.medscape.com/viewarticle/545401_side2 J. Biol. Chem., Vol. 269, Issue 39, 24511-24518, 09, 1994. Production of cholesterol-enriched nascent high density lipoproteins by human monocyte-derived macrophages is a mechanism that contributes to macrophage cholesterol efflux. HS Kruth, SI Skarlatos, PM Gaynor and W Gamble.

139 J. Clin. Invest. 110:899-904 (2002). Regulation and mechanisms of macrophage cholesterol efflux. Alan R. Tall, Philippe Costet and Nan Wang

140 Antioxidants in Human Health and Disease Edited by Tapan K. Basu, Norman J. Temple and Manohar

141 JAMA Meta-analysis of Antioxidants- Flawed Data, Biased Analysis, and Inappropriate Conclusions. Response to Jama Antioxident Study. Linus Pauling Institute, at: http://www.naturalproductsassoc.org/site/ DocServer/Response_to_JAMA_Antioxidant_Study_2-27-07.pdf?docID=3201

142 Harvard University Health Information at: http://huhs.harvard.edu/HealthInformation/Cholesterol/IncreaseAntioxidants.htm

143 Betacarotene and other carotenoids as antioxidants J Am Coll Nutr. 1999 Oct;18(5):424-5.

144 Preventive action of vitamin C on nitrosamine formation. International journal for vitamin and nutrition research. {Int-J-Vitam-Nutr-Res-Suppl}, 1989, vol. 30, p. 109-13, 28 refs, ISSN: 0373-0883. Tannenbaum-S-R.

145 The Linus Pauling Institute, Oregon State University at http ://lpi.oregonstate.edu/ss02/suh.html

146 Vitamin C is an important cofactor for both adrenal cortex and adrenal medulla. Endocrine research, {Endocr-Res}, Nov 2004, vol. 30, no. 4, p. 871-5, 26 refs, ISSN: 0743-5800. Patak-P, Willenberg-H-S, Bornstein-S-R.

147 Harvard School of Public Health at http://www.hsph.harvard.edu/nutritionsource/vitamins.html

148 Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells. Cancer Lett 1996;110:41–8. Kuo SM.

149 Dietary flavonoids and cancer risk in the Zutphen Elderly Study. Nutr Cancer 1994: 22:175–84. Hertog M, Feskens EJM, Hollman PCH, et al.

150 Quercetin, an anti-oxidant bioflavonoid, attenuates diabetic nephropathy in rats. Clinical and Experimental Pharmacology and Physiology 31 (4), 244–248. Muragundla Anjaneyulu, Kanwaljit Chopra (2004)

151 Comparative bioavailability to humans of ascorbic acid alone or in a citrus extract. Am J Clin Nutr 1988;48:601–4. Vinson JA, Bose P.

152 Neurodegeneration from mitochondrial insufficiency: nutrients, stem cells, growth factors, and prospects for brain rebuilding using integrative management. Altern-Med-Rev 2005 Dec; 10(4):268-93, ISSN: 1089-5159. Kidd-P-M.

153 Coenzyme Q10: a review. Hosp Pharm. 2001;36(1):51-66. Al-Hasso.

154 Relative bioavailability of coenzyme Q10 formulations in human subjects. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition, {Int-J-Vitam-Nutr-Res}, 1998, vol. 68, no. 2, p. 109-13, ISSN: 0300-9831. Chopra-R-K, Goldman-R, Sinatra-S-T, Bhagavan-H-N.

155 University of Maryland Medical Centre website at : www.umm.edu/altmed/ConsSupplements/CoenzymeQ10cs.h

156 Antioxidative effect of dietary coenzyme Q10 in human blood plasma. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition, {Int-J-Vitam-Nutr-Res}, 1994, vol. 64, no. 4, p. 311-5, ISSN: 0300-9831. Weber-C, Sejersgård-Jakobsen-T, Mortensen-S-A, Paulsen-G, Hølmer-G.

157 CoQ10: "natural and essential" for the heart Better Nutrition, August, 1997 by James F. Scheer

158 Coenzyme Q-10 for migraine prophylaxis: The first RCT. Focus-Alternat-Complement-Ther 2005 Sep; 10(3):194-5, ISSN: 1465-3753. Sandor-P-S, Di-Clemente-L, Coppola-G, Saenger-U, Fumal-A, Magis-D, Siedel-L, Agosti-R-M, Schroenen-J.

159 Linus Pauling Institute, Oregon State University, at: lpi.oregonstate.edu/infocenter/othernuts/coq10

160 The role of coenzyme Q10 in heart failure. The Annals of pharmacotherapy, {Ann-Pharmacother}, Sep 2005 (epub: 26 Jul 2005), vol. 39, no. 9, p. 1522-6, 18 refs, ISSN: 1060-0280. Weant-Kyle-A, Smith-Kelly-M.

161 Coenzyme Q 10: a review. Ancient-Sci-Life 2002 Oct; 22(2):49-55, ISSN: 0257-7941. Singh-D, Jain-V, Saraf-S, Saraf-S.

162 Role of coenzyme Q10 in clinical medicine part II. Cardiovascular disease, hypertension, diabetes mellitus and infertility. Alternat-Med-Rev 1996 Sep; 1(3):168-75. Gaby-A-R.

163 Proc Natl Acad Sci U S A. 1995 September 26; 92(20): 9388–9391. The roles of coenzyme Q10 and vitamin E on the peroxidation of human low density lipoprotein subfractions. R Alleva, M Tomasetti, M Battino, G Curatola, G P Littarru, and K Folkers Institute of Biochemistry, Faculty of Medicine, University of Ancona, Italy.

164 Treatment options in knee osteoarthritis: the patient's perspective. Arch-Intern-Med 2004 Jun 28; 164(12):1299-1304, ISSN: 0003-9926. Fraenkel-L, Bogardus-S-T-Jr, Concato-J, Wittink-D-R.

165 Medical management of osteoarthritis of the knee and hip joints. Med-J-Aust 2004 Mar 1; 180(5):232-6, ISSN: 0025-729X. Grainger-R, Cicuttini-F-M.

166 This house believes that we should advise our patients with osteoarthritis of the knee to take glucosamine. Rheumatology-Oxford 2004 Jan; 43(1):100-1, ISSN: 1462-0324. Manson-J-J, Rahman-A.

167 Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J-Alternat-Complement-Med 2003 Feb; 9(1):161-8, ISSN: 1075-5535. Chainani-Wu-N.

168 Arthritis Research Campaign, February 2001 at: http://www.arc.org.uk/newsviews/press/feb2001/gluco.htm

169 UK Government Food Standards Agency at: http://www.eatwell.gov.uk/asksam/agesandstages/olderpeeps/

170 The clinical effects of manganese (Mn). Townsend-Lett 1998 Jul; 180:92-3. Blaurock-Busch-E.

171 Synovial fluid analysis, from the American College of Rheumatology

172 Arthritis with Nutritional Rehabilitation: A Case Report. Paul W. Franzen, Jr., D.C., D.A.C.R.B. at: http://www.ccptr.org/PF/arthritis.htm

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175 Reichelt A, Forster KK, Fischer M, et al. Efficacy and safety of iniramuscular glucosamine sul/ate in osteoarthritis of the knee. A randomised, placebo-controlled, double-blind study. ArzneimForschung 44: 75-80; 1994.

176 Yajaradul Y. Double-blind clinical evaluation of intra-articular glucosamine in out-patients with gonarthrosis. Clin Ther 3:336-343; 1981.

177 Introductory Anatomy: Joints, University of Leeds, at: http://www.leeds.ac.uk/chb/lectures/anatomy4.html

178 Joints, BBC Science, at: http://www.bbc.co.uk/science/humanbody/body/factfiles/joints/ball _and_socket_joint.shtml

179 Isoflavone treatment for acute menopausal symptoms. Cheng G, Wilczek B, Warner M, Gustafsson JA, Landgren BM. Menopause. 2007 Feb 6

180 Mosca L, Collins P, Herrington D M, et al. Hormone replacement therapy and cardiovascular disease : a statement for healthcare professionals from the American Heart Association. Circulation 2001; 104:499-503.

181 Managing the menopause. British Menopause Society Council consensus statement on hormone replacement therapy. Journal of the British Menopause Society 2003; Vol.9, No.3: 129-131

182 Million Women Study Collaborators. Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 2003; 362: 419-427 www.thelancet.com

183 Menopause Matters at http://www.menopausematters.co.uk/

184 Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women. Principal results for the Women's Health Initiative Randomized controlled trial JAMA 2002;288:321-333

185 Hulley S,Grady D,Bush T, et al. Randomised trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA 1998;280:605-613.

186 Writing group for the WHI study. Risks and benefits of estrogen plus progestin in healthy postmenopausal women. Principal results from the women’s health initiative randomised controlled trial. Journal of the American Medical Association 2002;288:321-333 http://jama.ama-assn.org/cgi/content/abstract/288/3/321

187 Columbia Electronic Encyclopedia, published by Columbia University Press

188 Passwater, Richard A. All About Antioxidants. Garden City Park, NY: Avery Publishing Group, 1998.

189 University of Maryland Medical Centre, at: http://www.umm.edu/ency/article/002418.htm

190 Penland, J. G., and P. E. Johnson. "Dietary Calcium and Manganese effects on Menstrual Cycle Symptoms." American Journal of Obstetrics and Gynecology (1993): 1417–23.

191 Rivera, Juan A., Teresita Gonzalez-Cossio, Mario Flores, et al. "Multiple Micronutrient Supplementation increases the Growth of Mexican Infants." American Journal of Clinical Nutrition 74 (November 2001): 657.

192 Griffith, H. Winter. Vitamins, Herbs, Minerals & supplements: the complete guide. Arizona: Fisher Books, 1998.

193 Encyclopedia of Alternative Medicine, by The Gale Group, Inc.

194 McGraw-Hill Encyclopedia of Science and Technology, 5th edition, published by The McGraw-Hill Companies, Inc 195 Knekt P, Reunanen A, Jarvinen R, Seppanen R, Heliovaara M, Aromaa A. Antioxidant vitamin intake and coronary mortality in a longitudinal population study. Am J Epidemiol 1994; 139:1180-9.

196 Harvard School of Public Health at http://www.hsph.harvard.edu/nutritionsource/vitamins.html

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203 Chan JM, Stampfer MJ, Giovannucci EL. What causes prostate cancer? A brief summary of the epidemiology. Semin Cancer Biol 1998;8:263-73.

204 Ginkgo: The end of Alzheimer's disease? Anonymous. Psychology Today. New York: Mar/Apr 2000.Vol.33, Iss. 2; pg. 46

205 Fat-free foods supplemented with soy stanol-lecithin powder reduce cholesterol absorption and LDL cholesterol Curtis A Spilburg, Anne C Goldberg, Janet B McGill, William F Stenson, et al. American Dietetic Association. Journal of the American Dietetic Association. Chicago: May 2003.Vol.103, Iss. 5; pg. 577

206 Varicose veins: Total health for legs Josephine Mahi. Total Health. Woodland Hills: Dec 1998/Jan 1999.Vol.20, Iss. 5; pg. 16

207 Complementary and alternative medicine: Applications and implications for cognitive functioning in elderly populations Laura L Adams, Robert J Gatchel, Carol Gentry. Alternative Therapies in Health and Medicine. Aliso Viejo: Mar 2001.Vol.7, Iss. 2; pg. 52

208 Alzheimer's disease Kaj Blennow, Mony J de Leon, Henrik Zetterberg. The Lancet. London: Jul 29-Aug 4, 2006.Vol.368, Iss. 9533; pg. 387

209 Don't forget your ginko! Karyn Siegel-Maier. Better Nutrition. Atlanta: Feb 1999.Vol.61, Iss. 2; pg. 20

210 Ginkgo may help people with Alzheimer's disease Victoria Dolby. Better Nutrition. Atlanta: Jan 1998.Vol.60, Iss. 1; pg. 18, 1 pgs

211 PulseClinical: A practical guide to complementary medicine Pulse. Tonbridge: Feb 8, 2007. pg. 46

212 PS (Phosphatidylserine) versus Ginkgo: Which is better for the aging brain? Parris M Kidd. Total Health. Woodland Hills: Jul/Aug 1997.Vol.19, Iss. 3; pg. 30.

213 ginkgo biloba Rianne Heffel. Better Nutrition. Atlanta: May 2006.Vol.68, Iss. 5; pg. 14

214 Food Allergy Relief: The Joys of Being Food-Allergy Free, the Natural Way Maria Werick, Barbara Lohse Knous. Journal of Nutrition Education. Hamilton: Nov/Dec 2001.Vol.33, Iss. 6; pg. 358

215 Protective effects of extract of Ginkgo biloba (EGb 761) on nerve cells after spinal cord injury in rats Q Ao, X-H Sun, A-J Wang, P-F Fu, et al. Spinal Cord. Houndsmills: Nov 2006.Vol.44, Iss. 11; pg. 662

216 Brain nutrients Dharma Singh Khalsa. Total Health. Woodland Hills: Nov/Dec 1999.Vol.21, Iss. 5; pg. 38

217 Integrated medicine and the prevention and reversal of memory loss Dharma Singh Khalsa. Alternative Therapies in Health and Medicine. Aliso Viejo: Nov 1998.Vol.4, Iss. 6; pg. 38

218 Ginkgo boosts memory and mental function Victoria Dolby Better Nutrition; Jul 1998; 60, 7; ProQuest Nursing & Allied Health Source pg. 14

219 Ginkgo Biloba: Enhance your circulation Hyla Cass. Total Health. Woodland Hills: Aug/Sep 2003.Vol.25, Iss. 4; pg. S19 220 Cancer Chemoprevention by Garlic and Garlic-Containing Sulfur and Selenium Compounds1-3 Karam El-Bayoumy, Raghu Sinha, John T Pinto, Richard S Rivlin. The Journal of Nutrition. Bethesda: Mar 2006. Vol.136, Iss. 3S; pg. 864S

221 Low Serum Selenium and Total Carotenoids Predict Mortality among Older Women Living in the Community: The Women's Health and Aging Studies1 Amanda L Ray, Richard D Semba, Jeremy Walston, Luigi Ferrucci, et al. The Journal of Nutrition. Bethesda: Jan 2006.Vol.136, Iss. 1; pg. 172

222 Staying Healthy with Nutrition: The Complete Guide to Diet and Nutritional Medicine Elson M. Haas M.D. Celestial Arts.

223 The Relevance of Selenium to Immunity, Cancer, and Infectious/Inflammatory Diseases Milly Ryan-Harshman, Walid Aldoori. Canadian Journal of Dietetic Practice and Research. Markham: Summer 2005.Vol.66, Iss. 2; pg. 98

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225 Selenium and antioxidant defenses as major mediators in the development of chronic heart failure. de Lorgeril M, Salen P. Heart Failure Reviews [NLM - MEDLINE]. Mar 2006.Vol.11, Iss. 1; pg. 13

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228 Journal of Orthomolecular Medicine, 12, 1997

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236 The Net Doctor at http://www.netdoctor.co.uk/diseases/facts/menopause.htm

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